A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance.CB002 charger for dell latitude 3520 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, t

read more

High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: possible association with apolipoprotein E2 isoform.

Partial deficiency in lipolysis usually results in only mild disturbances of lipid levels.However, when this is associated with impairment of the uptake of remnant particles and increased production of triglyceride-rich lipoproteins stimulated by environmental factors such as during normal pregnancy, chylomicronemia may ensue.We have previously rep

read more


Effects of Variable Eruption Source Parameters on Volcanic Plume Transport: Example of the 23 November 2013 Paroxysm of Etna

The purpose of the present paper is to investigate the effects of variable eruption source parameters on volcanic plume transport in the Mediterranean basin after the paroxysm of Mount Etna on 23 November 2013.This paroxysm was characterized by a north-east transport of ash and gas, caused by a low-pressure system in northern Italy.It is evaluated

read more